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Basic Info

Model NO.	Lingding477600-75-2
Colour	White
MW	312.38
Transport Package	Based on Customer′s Needs
Specification	1kg
Trademark	Lingding
Origin	Hebei, China
Production Capacity	9000 Kilogram/Kilograms Per Month

Product Description

Product Name:	Tofacitinib
Other Names:	CP-690550
CAS:	477600-75-2
MF:	C16H20N6O
MW:	312.38
Melting Pointd	/
EINECS:	689-145-4

In November 2012, the US FDA approved tofacitinib (also referred to as CP-690550) for the treatment of adult patients with moderate to severely active rheumatoid arthritis (RA) who have had an inadequate response or intolerance to metho-trexate. Tofacitinib is the first small molecule kinase inhibitor approved for the treatment of RA. Tofacitinib is an inhibitor of the four subtypes of Janus kinase (JAK): JAK1, JAK2, JAK3, and Tyk2. The JAKs are intracellular, nonreceptor tyrosine kinases that play important roles in the signal transduction pathway of many cytokines (e.g., interleukins 2, 4, 7, 9, 15, and 21) and are involved in the propagation of inflammation in RA. Tofacitinib acts by inhibiting the phosphorylation and activation of signal transducers and activators of transcription (STATs), thereby suppressing the production of inflammatory mediators in joint tissue. At the enzyme level, tofacitinib inhibits JAKs 1, 2, 3, and Tyk2 with IC50s of 3.2, 4.1, 1.6, and 34 nM, respectively. At the cellular level, tofacitinib inhibits the in vitro activities of JAK1/JAK2, JAK1/JAK3, and JAK2/JAK2 combinations with IC50s of 406, 56, and 1377 nM, respectively.CP-690550 is a pyrrole [2,3-d] pyrimidine derivative used as a Janus kinase inhibitor in the treatment of rheumatoid arthritis

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Shipping Terms
By Express	By Air	By Sea
Suitable for under 50kg Fast: 3-7 days Door to door service, easy to pick up the goods	Suitable for more than 50kg Fast: 3-7 days High cost Port to port, professional broker needed	Suitable for more than 500kg Slow: 7-45 days Low cost Port to port, professional broker needed