Puya Supply Baricitinib CAS 1187594-09-7 Treatment of Rheumatoid Arthritis
Puya Supply Baricitinib CAS 1187594-09-7 Treatment Of Rheumatoid Arthritis Product Name: BaricitinibSynonyms:
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Basic Info
CAS No. | 1187594-09-7 |
Formula | C16h17n7o2s |
EINECS | 691-421-4 |
Type | Pharmaceutical Intermediates |
Appearance | Powder |
Quality | Refined |
Colour | White |
Transport Package | 1kg/Aluminum Bag or 25kg/Drum |
Specification | 99% min |
Trademark | Puya |
Origin | China |
Production Capacity | 5000kilogram/Month |
Product Description
Puya Supply Baricitinib CAS 1187594-09-7 Treatment Of Rheumatoid Arthritis
Product Name: BaricitinibSynonyms: 1-(Ethylsulfonyl)-3-[4-(7H-pyrrolo[2,3-d]pyriMidin-4-yl)-1H-pyrazol-1-yl]-3-azetidineacetonitril e;Baricitinib;INCB 028050;LY 3009104;BARICITINIB;INCB28050;LY3009104;Baricitinib (LY3009104);2-(3-(4-(3H-Pyrrolo[2,3-d]pyriMidin-4-yl)-1H-pyrazol-1-yl)-1-(ethylsulfonyl)azetidin-3-yl)acetonitril e;Baricitinib/INCB 028050/LY3009104CAS: 1187594-09-7MF: C16H17N7O2SMW: 371.42EINECS: 691-421-4Product Categories: JAK;STAT;Inhibitor;JAK/STAT;Inhibitors;APIMol File: 1187594-09-7.mol
Baricitinib (olumiant) is a selective JAK2 and JAK1 inhibitor with less potency against JanusKinase, jak3orTYK2. This kinase and its associated signal transducer and activator of transcription (JAK-STAT) are the major intracellular pathways that control the magnitude and duration of signaling of cytokines to type I and type II cytokine receptors. These receptors lack intrinsic enzymatic activity signaling that can be mediated; Janus kinase\signaling and activator of transcription is phosphorylated via JAK enzymes, leading to STAT activation. Several inflammatory factors are involved in the pathogenesis of RA, including IL-6, granulocyte macrophage colony-stimulating factor, and (GM-CSF) factor. Interferon signaling is via the JAK-STAT signaling pathway. Therefore, JAK1 and JAK2 inhibitors target multiple RA-associated cytokine pathways, which may reduce the activation and proliferation of key immune cells in inflammatory cells. baricitinib has no effect on JAK3, which may be associated with common gamma-chain receptors. Common gamma-chain cytokines include IL-15 and IL-21, which primarily act to regulate lymphocyte activation, function, and proliferation.
Baricitinib CAS 1187594-09-7 of Chemical Properties
Melting point 212-215°Cdensity 1.56storage temp. -20°Csolubility Soluble in DMSO (up to 30 mg/ml) or in DMF (up to 50 mg/ml).form solidpka 11.66±0.50(Predicted)color White or off-whiteStability: Stable for 2 years from date of purchase as supplied. Solutions in DMSO or DMF may be stored at -20°C for up to 3 months.
Function and Application of Baricitinib CAS 1187594-09-7
Packing And Shipping
1.Preferentially DHL, FedEX or TNT for quantity less than 50kg, air shipping for 100kg above, sea shipping for quantity over 500kg.
2.For customers from Russia,Mexico,Turkey,Solvenia,Romania,etc,before placing an order,please kindly confirm if you can make clearance when goods reach your customs.
Shipping Terms | ||
By Express | By Air | By Sea |
Suitable for under 50kg Fast:3-4 days High cost Door to door service Easy to pick up the goods | Suitable for more than 50kg Fast:3-4 days High cost Airport to airport Professional broker needed | Suitable for more than 500kg Slow:15-30 days Low cost Port to port Professional broker needed |
Company Profile
Anhui puya biological technology co.,ltd was established in Hefei. Registered capital is 5 million. It is specialized in manufacture plant extract, API and chemicals raw material powder, food additives and oil. which are applied to skin care, healthcare, weight loss products, sex improvement, and pharmaceuticals. We will uphold honesty and pragmatic, innovative and enterprising service purposes, and provide a variety of quality services to our customers at abroad. It aims at supplying good product and comfort service. The strict quality control is to meet the customer's requirement, to get a highly praised and to be high quality supplier. If you have any question, or need samples, please feel free to contact us.
FAQ
Q1. What's the MOQ?
A: Usually 1 kg. It is based on the different product. Some are 1g and some are 1 ton. Please be free to consult our salesman.
Q2. What's the shipping time?
A: If in stock, we will ship it out immediately. By FedEx will be 3~5 days to you.
Q3. If I need less than the MOQ, is it possible?
A: Yes. Please be free to consult our salesman.
Q4. Can you supply the free sample?
A: Usually it is possible. but the shipping cost be paid by customers. It based on the different product. Please be free to consult our salesman.
Q5. How to store the product?
A: Store in cool and dry place. It must be in well closed containers. The shelf life will be 2 years.
Q6: What's your main payment method?
A: T/T, trade assurance, west union, money gram.
Q7: Do you have COA, MSDS, CO, Health certificate, form 9 or other certificate?
A: Yes, we have. pls be free to contact us to get updated one.
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