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DESCRIPTION

Basic Info

Model NO.	MB0107
Host	Mouse
Reactivity	Human,Mouse,Rat
Applications	Wb
Application_All	Wb: 1:500~1:1000
Transport Package	Refrigerated Transport
Specification	100ug/1mg
Trademark	Bioworld
Origin	China
HS Code	300219000
Production Capacity	3000 Vials

Product Description

Product Name	TAB1 monoclonal antibody
Catalog No.	MB0107
Swiss-Prot	Q15750
Host	Mouse
Reactivity	Human,Mouse,Rat
Applications	WB
Application_all	WB: 1:500~1:1000
BiowMW	~ 60 kDa
Alternative Name	TGF-beta-activated kinase 1 and MAP3K7-binding protein 1; Mitogen-activated protein kinase kinase kinase 7-interacting protein 1; TGF-beta-activated kinase 1-binding protein 1; TAK1-binding protein 1; TAB1; MAP3K7IP1
Purification&Purity	The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Conjugate	Unconjugated
Modification	Unmodification

Primary ab dilution: 1:1000Primary ab dilution: 1:1000

Background :
The protein encoded by this gene was identified as a regulator of the MAP kinase kinase kinase MAP3K7/TAK1, which is known to mediate various intracellular signaling pathways, such as those induced by TGF beta, interleukin 1, and WNT-1. This protein interacts and thus activates TAK1 kinase. It has been shown that the C-terminal portion of this protein is sufficient for binding and activation of TAK1, while a portion of the N-terminus acts as a dominant-negative inhibitor of TGF beta, suggesting that this protein may function as a mediator between TGF beta receptors and TAK1. This protein can also interact with and activate the mitogen-activated protein kinase 14 (MAPK14/p38alpha), and thus represents an alternative activation pathway, in addition to the MAPKK pathways, which contributes to the biological responses of MAPK14 to various stimuli. Alternatively spliced transcript variants encoding distinct isoforms have been reportedProduct :
0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.Specificity :
TAB1 monoclonal antibody detects endogenous levels of TAB1 protein.Immunogen :
Synthetic peptide, corresponding to Human TAB1.