Vp16 Tagpolyclonal Antibody

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Vp16 Tagpolyclonal Antibody

Vp16 Tagpolyclonal Antibody

Background HSV evades the immune system through interference with MHC class I antigen presentation on the cell surface,

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DESCRIPTION

Basic Info
Model NO. BS65868
Certification CE, ISO9001
Host Rabbit/Mouse
Reactivity Human,Mouse,Rat
Transport Package Refrigerated Transport
Specification 100ug/1mg
Trademark Bioworld
Origin China
HS Code 300219000
Production Capacity 3000 Vials
Product Description

Catalog No.BS65868
Product NameVP16 tagPolyclonal Antibody
ApplicationsWB,
Alternative NameVP16_HHV1F;UL48; Tegument protein VP16; Alpha trans-inducing protein; Alpha-TIF; ICP25; Vmw65
Swiss-ProtP04486
HostRabbit
ReactivityHuman herpesvirus 1
Application_allWB=1:500-2000
Product0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 122% Glycerol.
Purification&Purityaffinity purified by Protein A
Storage&StabilityStore at 4°C short term. Aliquot and store at -41°C long term. Avoid freeze-thaw cycles.
SpecificityVP16 tag Polyclonal Antibody detects endogenous levels of VP16 tag protein.
BiowMW~51 kDa
Note
ImmunogenKLH conjugated synthetic peptide derived from HSV-1 VP16:391-490/490aa


  • Primary: Anti-VP16 tag at 1/1000 dilution

Background

HSV evades the immune system through interference with MHC class I antigen presentation on the cell surface, by blocking TAP or the transporter associated with antigen processing induced by the secretion of ICP-47 by HSV. In the host cell, TAP transports digested viral antigen epitope peptides from the cytosol to the endoplasmic reticulum, allowing these epitopes to be combined with MHC class I molecules and presented on the surface of the cell. Viral epitope presentation with MHC class I is a requirement for activation of cytotoxic T-lymphocytes (CTLs), the major effectors of the cell-mediated immune response against virally-infected cells. ICP-47 prevents initiation of a CTL-response against HSV, allowing the virus to survive for a protracted period in the host.

Vp16 Tagpolyclonal Antibody

Vp16 Tagpolyclonal Antibody

Vp16 Tagpolyclonal Antibody

Vp16 Tagpolyclonal Antibody

Vp16 Tagpolyclonal Antibody