Products

DESCRIPTION

Basic Info

Model NO.	BS6325
Supply Type	OBM(Original Brand Manufacturing)
Usage Mode	For external use
Suitable for	Elderly, Adult
Type	Biological Diagnostic Reagents
Application	for Diagnosis, for Therapy, for Prevention
Form	Liquid
Certification	CE, ISO9001
Host	Rabbit/Mouse
Reactivity	Human, Mouse, Rat
Transport Package	Refrigerated Transport
Specification	100ug/1mg
Trademark	Bioworld
Origin	China
HS Code	300219000
Production Capacity	3000 Vials

Product Description

Catalog No.	BS6325
Product Name	ANTXR2 polyclonal antibody
Applications	WB IHC IF
Alternative Name	Anthrax toxin receptor 2; Capillary morphogenesis gene 2 protein; CMG-2; ANTXR2; CMG2
Swiss-Prot	P58335
Host	Rabbit
Reactivity	Human,Mouse,Rat
Application_all	WB: 1:500~1:2000 IHC: 1:50~1:200 IF: 1:50~1:200
Product	Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Purification&Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage&Stability	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity	ANTXR2 polyclonal antibody detects endogenous levels of ANTXR2 protein.
BiowMW	~ 54 kDa
Note	For research use only, not for use in diagnostic procedure.
Immunogen	Recombinant fusion protein containing a sequence corresponding to amino acids 339-488 of human ANTXR2 (NP_477520.2).

• 
  Western blot analysis of extracts of various cell lines, using ANTXR2 Rabbit pAb at 1:1000 dilution.
• 
  Immunohistochemistry of paraffin-embedded human stomach using ANTXR2 antibody at dilution of 1:100 (40x lens).
• 
  Immunohistochemistry of paraffin-embedded mouse kidney using ANTXR2 antibody at dilution of 1:100 (40x lens).

Background

Anthrax toxin receptor 2 (ATR2), also designated capillary morphogenesis gene 2 (CMG2), is a cellular receptor for anthrax toxin. ATR2/CMG2 is a type 1 membrane protein that includes an extracellular von Willebrand factor A (VWA) domain with a metal ion-dependent adhesion site (MIDAS) motif. ATR2/CMG2 binds to protective antigen (PA) which is one of the three monomeric proteins which are released as anthrax toxin from Bacillus anthracis. Once bound, PA facilitates the delivery of the other two proteins, edema factor (EF) and lethal factor (LF), into the cytosol. Mutations in the gene ATR2/CMG2 result in inhibition of binding by the vWA domain, associated with infantile systemic hyalinosis (ISH) and juvenile hyaline fibromatosis (JHF). ISH and JHF are rare stiff-skin syndromes characterized by hyaline desposition in various organs, especially the skin and gingiva.