Antxr2 Polyclonal Antibody

Products

Antxr2 Polyclonal Antibody

Antxr2 Polyclonal Antibody

Background Anthrax toxin receptor 2 (ATR2), also designated capillary morphogenesis gene 2 (CMG2), is a cellular recepto

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DESCRIPTION

Basic Info
Model NO. BS6325
Supply Type OBM(Original Brand Manufacturing)
Usage Mode For external use
Suitable for Elderly, Adult
Type Biological Diagnostic Reagents
Application for Diagnosis, for Therapy, for Prevention
Form Liquid
Certification CE, ISO9001
Host Rabbit/Mouse
Reactivity Human, Mouse, Rat
Transport Package Refrigerated Transport
Specification 100ug/1mg
Trademark Bioworld
Origin China
HS Code 300219000
Production Capacity 3000 Vials
Product Description

Catalog No.BS6325
Product NameANTXR2 polyclonal antibody
ApplicationsWB IHC IF
Alternative NameAnthrax toxin receptor 2; Capillary morphogenesis gene 2 protein; CMG-2; ANTXR2; CMG2
Swiss-ProtP58335
HostRabbit
ReactivityHuman,Mouse,Rat
Application_allWB: 1:500~1:2000 IHC: 1:50~1:200 IF: 1:50~1:200
ProductRabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Purification&PurityThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage&StabilityStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
SpecificityANTXR2 polyclonal antibody detects endogenous levels of ANTXR2 protein.
BiowMW~ 54 kDa
NoteFor research use only, not for use in diagnostic procedure.
ImmunogenRecombinant fusion protein containing a sequence corresponding to amino acids 339-488 of human ANTXR2 (NP_477520.2).


  • Western blot analysis of extracts of various cell lines, using ANTXR2 Rabbit pAb at 1:1000 dilution.

  • Immunohistochemistry of paraffin-embedded human stomach using ANTXR2 antibody at dilution of 1:100 (40x lens).

  • Immunohistochemistry of paraffin-embedded mouse kidney using ANTXR2 antibody at dilution of 1:100 (40x lens).

Background

Anthrax toxin receptor 2 (ATR2), also designated capillary morphogenesis gene 2 (CMG2), is a cellular receptor for anthrax toxin. ATR2/CMG2 is a type 1 membrane protein that includes an extracellular von Willebrand factor A (VWA) domain with a metal ion-dependent adhesion site (MIDAS) motif. ATR2/CMG2 binds to protective antigen (PA) which is one of the three monomeric proteins which are released as anthrax toxin from Bacillus anthracis. Once bound, PA facilitates the delivery of the other two proteins, edema factor (EF) and lethal factor (LF), into the cytosol. Mutations in the gene ATR2/CMG2 result in inhibition of binding by the vWA domain, associated with infantile systemic hyalinosis (ISH) and juvenile hyaline fibromatosis (JHF). ISH and JHF are rare stiff-skin syndromes characterized by hyaline desposition in various organs, especially the skin and gingiva.

Antxr2 Polyclonal Antibody

Antxr2 Polyclonal Antibody

Antxr2 Polyclonal Antibody

Antxr2 Polyclonal Antibody

Antxr2 Polyclonal Antibody