Antxr2 Polyclonal Antibody
Background Anthrax toxin receptor 2 (ATR2), also designated capillary morphogenesis gene 2 (CMG2), is a cellular recepto
Send your inquiryDESCRIPTION
Basic Info
Model NO. | BS6325 |
Supply Type | OBM(Original Brand Manufacturing) |
Usage Mode | For external use |
Suitable for | Elderly, Adult |
Type | Biological Diagnostic Reagents |
Application | for Diagnosis, for Therapy, for Prevention |
Form | Liquid |
Certification | CE, ISO9001 |
Host | Rabbit/Mouse |
Reactivity | Human, Mouse, Rat |
Transport Package | Refrigerated Transport |
Specification | 100ug/1mg |
Trademark | Bioworld |
Origin | China |
HS Code | 300219000 |
Production Capacity | 3000 Vials |
Product Description
Catalog No. | BS6325 |
---|---|
Product Name | ANTXR2 polyclonal antibody |
Applications | WB IHC IF |
Alternative Name | Anthrax toxin receptor 2; Capillary morphogenesis gene 2 protein; CMG-2; ANTXR2; CMG2 |
Swiss-Prot | P58335 |
Host | Rabbit |
Reactivity | Human,Mouse,Rat |
Application_all | WB: 1:500~1:2000 IHC: 1:50~1:200 IF: 1:50~1:200 |
Product | Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2 |
Purification&Purity | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE). |
Storage&Stability | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. |
Specificity | ANTXR2 polyclonal antibody detects endogenous levels of ANTXR2 protein. |
BiowMW | ~ 54 kDa |
Note | For research use only, not for use in diagnostic procedure. |
Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 339-488 of human ANTXR2 (NP_477520.2). |
Western blot analysis of extracts of various cell lines, using ANTXR2 Rabbit pAb at 1:1000 dilution.
Immunohistochemistry of paraffin-embedded human stomach using ANTXR2 antibody at dilution of 1:100 (40x lens).
Immunohistochemistry of paraffin-embedded mouse kidney using ANTXR2 antibody at dilution of 1:100 (40x lens).
Background
Anthrax toxin receptor 2 (ATR2), also designated capillary morphogenesis gene 2 (CMG2), is a cellular receptor for anthrax toxin. ATR2/CMG2 is a type 1 membrane protein that includes an extracellular von Willebrand factor A (VWA) domain with a metal ion-dependent adhesion site (MIDAS) motif. ATR2/CMG2 binds to protective antigen (PA) which is one of the three monomeric proteins which are released as anthrax toxin from Bacillus anthracis. Once bound, PA facilitates the delivery of the other two proteins, edema factor (EF) and lethal factor (LF), into the cytosol. Mutations in the gene ATR2/CMG2 result in inhibition of binding by the vWA domain, associated with infantile systemic hyalinosis (ISH) and juvenile hyaline fibromatosis (JHF). ISH and JHF are rare stiff-skin syndromes characterized by hyaline desposition in various organs, especially the skin and gingiva.Related Products
-
Recombinant Parvovirus Protein
-
GEB 0.8ml Natural Low Retention Pre-Sterilized Individual Wall V-shape Bottom 96-Round-Deep-Well Plate Tapered PP Wholesale Medical Biology Consumable Labware
-
Solgar, Whey to Go, Whey Protein Powder, Natural Chocolate Flavor, 16 Oz (453.5 g)
-
Sepapure FF Ni-Nta 5 Ml, for His-Tag Purification Column