Products

DESCRIPTION

Basic Info

Model NO.	BS1965
Certification	CE, ISO9001
Host	Rabbit/Mouse
Reactivity	Human, Mouse, Rat
Transport Package	Refrigerated Transport
Specification	100ug/1mg
Trademark	Bioworld
Origin	China
HS Code	300219000
Production Capacity	3000 Vials

Product Description

Catalog No.	BS1965
Product Name	Ptx3 (Y27) polyclonal antibody
Applications	WB IHC IF
Alternative Name	Pentraxin-related protein PTX3; Pentaxin-related protein PTX3; Tumor necrosis factor alpha-induced protein 5; TNF alpha-induced protein 5; Tumor necrosis factor-inducible gene 14 protein; TSG-14; TNFAIP5; TSG14; PTX3
Swiss-Prot	P26022
Host	Rabbit
Reactivity	Human,Mouse,Rat
Application_all	WB: 1:500~1:1000 IHC: 1:50~1:200 IF: 1:50~1:200
Product	Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Purification&Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage&Stability	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity	Ptx3 (Y27) polyclonal antibody detects endogenous levels of Ptx3 protein.
BiowMW	~ 41 kDa
Note	For research use only, not for use in diagnostic procedure.
Immunogen	Synthetic peptide, corresponding to the N-terminal of Human Ptx3.

• 
  Western blot (WB) analysis of Ptx3 (Y27) polyclonal antibody at 1:500 dilution Lane1:SGC7901 whole cell lysate(40ug) Lane2:786-O whole cell lysate(40ug) Lane3:HEK293T whole cell lysate(40ug) Lane4:The Brain tissue lysate of Rat(40ug) Lane5:The Brain tissu
• 
  Immunohistochemistry (IHC) analyzes of Ptx3 (Y27) pAb in paraffin-embedded human breast carcinoma tissue at 1:100.

Background

Pentraxins are a protein superfamily that is characterized by a cyclic multimeric structure. Ptx3, also known as tumor necrosis factor-stimulated gene sequence-14 (TSG14), is a secreted pattern-recognition receptor that has a non-redundant role in resistance to selected microbial agents. Ptx3 belongs to the family of "long pentraxins", which have C-terminal pentraxin domains and novel amino-terminal domains. Ptx3 binds selected pathogens, including Aspergillus fumigatus, Pseudomonas aeruginosa and Salmonella typhimurium. It is synthesized in IgA glomerulonephritis and activates mesangial cells. Secretion of Ptx3 in adipose cells can be induced by TNF . Ptx3 is also involved in amplification of inflammatory reactions and regulation of innate immunity. The human PTX3 gene maps to chromosome 3q25.